Tag H3

ANTIHISTAMINES – Receptor Blocking

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H1, H2, H3, H4 Receptor Blockers

” Histamine receptors are located throughout the human body and have been classified into categories H1, H2, H3, and H4.Generally speaking, H1 receptors account for neuronal and nervous system sites, H2 are more related to stomach and digestive function, H3 receptors are found in the brain, and H4 are found in organs and bone marrow. Both H1 and H2 receptors are found in airway tissues, skin tissue, and immune cells.” Found on this website — https://www.optimusmedica.com/otc-antihistamines/#:~:text=Histamine%20receptors%20are%20located%20throughout%20the%20human%20body,H4%20are%20found%20in%20organs%20and%20bone%20marrow.

What has worked for me is in immediate flare of a critical reaction, I choose to take a Generation 1 antihistamine which is Diphenhydramine (Benedryl). However, long term use has indicated that it can cause or create dementia/Alzheimer’s or at least exasperates symptoms. I had been using Diphenhydramine for years, because the allergy shots never worked, and I’m allergic to steroids and Prednisone. So I gave that up. I had to do something.

FAMOTIDINE
Cetirizine

Once I verified exactly what symptoms I was suffering from, and then figured out what receptors I needed to block, and what drugs coordinated with the ones I searched up. What worked for me was H1 and H2 blockers, which was Cetirizine (Zyrtec) and Famotidine (Pepcid AC)

Since I already was diagnosed with Fibromyalgia, and Neuropathy (even my feet were killing me and I wasn’t on them) along with my GI tract flaring, I knew that the only way for me to calm down my whole body was to block my H1 receptors and H2 receptors from antihistamine. My skin was reacting as well by the time I was diagnosed. Showers felt like whole body tattoos all at once, even the water hurt my skin like tiny needles. Each person is different, and each person will have different results and responses.

For Immediate Reactions, Like Hives, Dephenhydramine

**Note: I was a guinea pig, and my primary physician was on board. He told me, “a serving suggestion is very literally a suggestion, you can take MORE of a antihistamine than what is suggested, so it took a lot of trying one , and upping the dose. My dosage is 4 times a day. 30 minutes before eating , Morning wake-up, Lunch, Dinner, and then 30 minutes before bed, to account for the histamine dump while I sleep to fight the insomnia and night sweats, when I forget to take them.

**Always check with your primary physician when taking OTC or Prescription medications. They are not pharmacy technicians, but it is important to discuss uses if you are on any other medications as well!**

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