Tag histamine

Unveiling Mast Cell & Fibromyalgia Connection

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Fibromyalgia comes with many comorbid conditions that can be directly affected by mast cell reactions. Some conditions can include bladder pain syndrome/interstitial cystitis (BPS/IC), gastrointestinal symptoms (GI), neurologic inflammation and pain, and mast cell dysfunction and disorders.

Mast cells in the skin are the guardians that quickly react to stimuli that disturb a person’s homeostasis. Mast Cells (MCs) are found in the mucous membranes of the respiratory along with the digestive tract along with submucosa and connective tissue adjacent to the conjunctiva and skin. MCs are part of the pathogenesis of allergic, auto inflammatory and cancer disease as well.

Since our skin is the largest organ of the body that protects us from external physical, chemical, along with microbiological factors. MCs are one of the representatives that react first in the immune response. MCs are part of both the innate and adaptive immune responses.

Neurological Inflammation & Pain

“Thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine, IL-1β, IL-6 and TNF, as well as calcitonin-gene related peptide (CGRP), HK-1 and SP. These molecules could either stimulate thalamic nociceptive neurons directly, or via stimulation of microglia in the diencephalon. As a result, inhibiting mast cell stimulation could be used as a novel approach for reducing pain and the symptoms of FMS,” states the PubMed website.

Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC)

“Mast cells involved in allergic reactions are distributed throughout the blood vessels, lymph glands, and nerves of the bladder, as well as the bladder smooth muscle and mucosa. Mast cells activated by the involvement of neurological, immune, and endocrine factors are thought to play a central role in the progression of IC/BPS in many patients,” states the International Neurology Journal website.

Gastrointestinal Pain & Inflammation

“Diet modification in patients with fibromyalgia by specific histamine release test improves certain clinical parameters related to the symptoms of the digestive sphere, compared to the control group. Our work opens a possible way of non-pharmacological treatment to improve some symptoms of this very prevalent disease,” states the Rheumatologia website.

The identification of the DAO enzyme deficiency in FMS patients has made it obvious that histamine and mast cell reactions directly correlate for a lot of the sub symptoms of Fibromyalgia and it’s associated pain.

DAO deficiency can create a histamine intolerance in FM patients. Photo cred:meineresterampe/Pixabay

“Associations between fibromyalgia symptoms and candidate variants of the AOC1 gene in DAO enzyme activity. Identification of reduced DAO activity may improve the quality of life and treatment of symptoms in fibromyalgia patients.” states the Frontiers website when discussing Frontiers in Genetics.

DAO is an enzyme stored in tissues but primarily are found in the renal and intestinal mucosa. DAO’s purpose is to catabolize, or break down, histamine and diamines. Deficiency in DAO can create Histamine Intolerance (HIT). This can lead to neurological, gastrointestinal, and epidermal disorders.

What is recommended to assist patients in treatment is an elimination diet of high histamine foods can help patients along with recommendations of the following:

“Inhibitors of mast cells would be useful in the treatment of FMS. Natural molecules could include the flavonoids, luteolin and tetramethoxyluteolin, alone or in combination with other substances selected to reduce stress. Other natural molecules could include palmitoylethanolamide, which apparently inhibits neuro-inflammation and reduces pain,” states the Frontiers in Cellular Neurology website .

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https://original.newsbreak.com/@misty-romack-1637118/3136545642454-mast-cells-fibromyalgia-unveiling-a-connection

Getting back to ME!

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When I hit a plateau, I search for the next step in treatment to improve. So that’s what I have been up to.

My focus and mental clarity are spot on, with the simple stuff, like taking forskolin, and Rutin, along with my antihistamines. However, I have a tendency to keep looking even when things are good, in case I missed something, then when it goes to plateau, I dig for more!

Everywhere I go, I start discussing illness in forums and groups, you get varying levels of acceptance. What I mean by that is, there are patients that accept their illnesses and want to “live with them” for the rest of their lives, and then there’s the patients constantly at “unrest”, basically not comfortable with being sick, that’s me. I’m not comfortable knowing that I have to live like this the rest of my life. I ACCEPT the fact that there is possibility I may have to, but it will never stop me from continuing to fight against it. After all, as the world turns, every day there is new science. Something new coming to the forefront. This is a revolutionary time in science and medicine.

This was a photo of myself right before I started the MTHFR journey.

Recently when studying histamine intolerance, I discovered a list of medications and things that can exacerbate histamine intolerance, and then I discovered the caveat. Even with the use of all the antihistamines I was taking and my great success with it, they BLOCK the histamines from attaching to the appropriate receptors so that you do not get symptoms. However, it does not degrade the histamine build up in your body. Which means then the histamines float around and find a new place to attach themselves to, leading to new or different symptoms.

I’m diving into that research as I go, however there had been a turn of events in my life, that turned me to studying MTHFR gene expressions, and how your body can’t methylate if you have certain genetic “SNIPS” as they refer to them. I haven’t done the testing, but I jumped on the bandwagon anyway, starting to treat myself “blindly” as is always my method since I started searching for my own health. I’m treating myself so far with Methyl folate and Vitamin B complex and Glutathione.

In one month, I no longer have to take all the antihistamines. Nothing. I have no pain, no arthritic pain, no fibromyalgia pain, and I am at full brain faculty first thing when I wake up. No longer do I sit with my caffeine for two hours waiting for my brain to clear, I’m crisp as a piece of paper first thing in the morning. I can now eat peanut butter again after 17 years, I’m pretty stoked about that. Now it doesn’t mean that I can’t have overactive histamine responses, I’m actually built to, but my body is now breaking down a great deal of histamine on its own through this methylation journey so that I’m not toxic, but if I overexpose myself, I do find myself reaching for my Cetirizine. So far, it’s only occurred twice, and only one pill for an entire day.

In our region currently, we have high tree pollen concentrations, and the farmers are out spraying, plowing and working the fields. That had put me into a migraine yesterday out of the blue, but I literally overexposed myself to more histamine than my body knew what to do with.

***NOTE: the next few links shared for Newsbreak is an affiliate link that the author can make a commission from. I appreciate the support, if you do decide to sign up!***

In my free time, I am now writing for NEWSBREAK….an app that gives you up to date information in your local area. When I’m not working on my book, I figured if I’m going to do the research to help myself, I might as well help others, so here I am. Sharing what I learn as I go, as far as fibromyalgia, Mast Cell Activation, and IBS, along with various other discoveries, and giving local information reports on barometric pressure and allergy reports in my local area.

If you feel that you would like to become a contributor or writer for your local area, it is a legitimate way to make passive income when your body is restricted in movement. I highly suggest you look into it. Just follow the link here to become a writer…. CREATOR REFERRAL.

The Easter Egg Hunt for Healing!

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Looking for the answers on how to heal.

Swinging an Easter basket in one hand wearing her new yellow frilly dress, and black shiny patent leather shoes running through the tufts of thick green grass, searching frantically for colorful candy filled plastic easter eggs, that was me. Each egg found would come with candy, money, or a prize, and never left a recipient in disappointment with each brightly colored find. Family who hid the eggs would even get devious, sometimes you had to search high and low, even though I was a shorter version of most humans. Easter was so much fun! I also learned an invaluable lesson from Easter Egg hunts. Never leave any stone unturned, check every nook and cranny, even check the gutters and trashcans.

Plastic Easter Eggs
Easter Baskets for Adults & Children

My search for knowledge, sincerely comes from what I learned Easter Egg Hunting, and I implore you and our younger generations to do the same. When it comes to your health, when it comes to life, or anything that you need to gain knowledge for or from. One valuable piece of wisdom my father imparted on me as a child was, “No matter what the situation, your EDUCATION can never be taken from you. No one, the only one that can deny you EDUCATION is yourself.” I’ve carried that with me forever, and I share that sentiment with any human being I can.

My search for knowledge about my health, started at home. Gutters were first, I started looking at my bowels. What I was consuming and what was coming out are VERY important. Then, I began to search higher. Once I knew I wasn’t poisoning myself, to the best of my knowledge, I got online and started Googling. The one thing everyone tells you not to do, but remember, I don’t listen. I was looking for answers on how to heal my brain, and how to thwart my Mast Cell reactions and all the histamine my body was producing. I needed to do something and pronto.

I know what you are saying to yourself, “Why didn’t she go to an allergist?” Funny story, I did that too. I was allergic to practically everything, and then I was allergic to the steroids that was supposed to counteract the reactions to the shots. I went in more miserable than when I came out. It wasn’t working, or worth the misery I was putting myself through. All the allergist wanted to do was keep giving me the shots, even that doctor didn’t really look into WHY my body seemed to react to EVERYTHING. I fired that doctor too.

My tunnel of light was closing quickly, it’s hard to explain. In a sense, I knew I was losing my thought processing ability, I was in fight or flight mode, just trying out how to figure things out, to save my life. (This also raises histamine levels, cortisol levels, and sends you into a stress histamine response as well. With each waking day, I knew I was step closer to losing my grip on reality.) At one point, the only thing I could manage to do was crossword puzzles, and that took FOREVER just to get one done. I used to be an ace at those as a child, I could have one done in less than 3 minutes.

Popped open my laptop and went online to find “Easter Eggs” of information. I searched many things, but educating myself on histamine was the start.